My research group at the University Medical Center Göttingen (UMG) investigates cancer metabolism and metabolic plasticity during metastatic progression. My research focuses on identifying metabolic vulnerabilities in pancreatic cancer and other entities across the different stages of the metastatic cascade. To uncover novel therapeutic targets for organ metastasis, we employ state-of-the-art technologies, including in vitro and in vivo CRISPR screening approaches. In addition, my laboratory integrates comprehensive metabolomics and lipidomics analyses of cancer cells, tumor tissues, and other biological samples to characterize dynamic metabolic adaptations and capture the mechanisms underlying metabolic plasticity during cancer progression. Funding for this position is provided by the “UMG2032

• Excellence through Focus” project, funded by zukunft.niedersachsen, the joint science funding program of the Lower Saxony Ministry of Science and Culture and the Volkswagen Foundation.

Ihre Aufgaben

• Maintaining and operating LC/MS equipment (Orbitrap System), troubleshooting technical difficulties and running the sample analysis pipeline • Optimize protocols for metabolomics and bring forward new method development to analyze small molecules (polar and unpolar); • Processing, extracting and analysis of different biological samples (e.g. tissue samples, cell culture samples, plasma) for metabolomics and lipidomics • Experience with stable isotope labeling is a prerequisite; • Interpret metabolic pathway alterations to answer biological questions; • Manage sample submission, tracking, data organization, and laboratory information management systems for the analysis pipeline; • Stay current with emerging technologies and methodologies in metabolomics/ lipidomics and prepare detailed technical reports and SOPs; • Present and communicate research results internal scientific meetings

Ihre Qualifikationen

• You are a curious and enthusiastic scientist who can work independently but also in a team; • Extensive hands-on experience with LC-MS/MS systems and strong knowledge of MS principles; • Experience with metabolomics data processing software (e.g., El-MAVEN, Compound Discoverer, LipidSearch); • Knowledge of metabolic pathways and biochemistry is a prerequisite; • Proficiency in bioinformatics (e.g. PCA, MVA, limma and more), big data management and data visualization including pathway analysis tools (MetaboAnalyst, Cytoscape); • Experience with other 'omics platforms (proteomics, genomics, transcriptomics) is an advantage; • Communicate effectively within the team, internal and external collaborators, clinicians and other scientists; • Strong analytical and problem-solving skills with strong attention to detail; • Applicants should hold a PhD in the life sciences, such as Biology, Medical Biology, Biochemistry or a related subject. • Fluent English language skills (written and spoken) are required.

Wir bieten

• You will work in a high-impact research field with biomedical relevance embedded in the collaborative environment of the Göttingen Campus including several supportive facilities and inspiring research consortia. • Small, international and diverse research group with a strong team spirit and an open-minded, collaborative and respectful working atmosphere. • The UMG is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. • We further strive for gender and diversity equality. We welcome applications from all backgrounds.

How to apply We are looking forward to receive your applications including a motivation letter, a CV, certificates and contact details for at least two references compiled as a single PDF via the system. If you have any questions regarding the advertised position, do not hesitate to contact Dr. Felix Vogel ([email protected]) for further information.

We look forward to receiving your application!